RESEARCH ON EFFECTS OF ASHITABA
By Dr. Kevin Lance [ones, L.Ac., O.M.D.]
Little is known about the world of Herbal Medicine. Of all the plant species in the world, only five percent (5%) have been catalogued. Of that five percent that have been catalogued, a full one quarter (1/4) or twenty – five percent (25%) have medicinal qualities. There is the example of Taxol, an anti-uterine cancer drug that is derived from the bark of the Yu tree.
Another shinning example of a newly discovered herbal medicine is ASHITABA. Its name literally translates to Japanese as "Early Growth" or "Tomorrow’s Leaf". It was named so because of its ability to grow very fast and exhibit a strong Qi or energetic life force.
PROPERTIES & THERAPUTIC USES OF ASHITABA
Kidney Yin and Yang with Qi and Xue
In this section I will endeavor to explain the therapeutic actions of Angelica Keiskei Koidzumi or ASHITABA in terms of Traditional Chinese Medicine as practiced currently in the People's Republic of China. One of the fundamental actions of ASHITABA is that it is great at activating Qi and Xue (Blood). The application for this is apparent in the treatment in the menstrual problems. It removes stagnation in the uterus, which will help with many menstrual difficulties. It also increases blood flow (activates Qi and Blood). ASHITABA which can be used by it self alone, increases Kidney Yin and Yang Qi.
Kidney Yang Qi and Yang Xu
The increase of the Kidney Yang Qi will act as a diuretic and increase the urine output. In Japan, ASHITABA is used to treat hypertension. As a diuretic it has no side effects such as western medicines frequently have. It increases the libido (sex drive) for those persons with Kidney Yang Xu (deficiency).
Kidney Yin Xu
In terms of the increase in Kidney Yin Xu (deficiency), this herb is wonderful in treating the problem of Peri – menopause. With a Kidney Yin Xu (deficiency) one of the cardinal symptoms in women is related to their irregular or no menstruation. The usual four to six years of peri – menopause that women in their middle forties to early fifties in age experience could be made much more comfortable with the use of ASHITABA. Since this herb warms the uterus, it is very useful in treating menstrual cramps and pain, regardless of the age of the patient.
ASHITABA Good for Lactagogue
ASHITABA is a useful Lactagogue, that is, an agent which induces the secretion of mother's milk. There is an anecdotal evidence from Japan concerning a cow that was fed with ASHITABA and it recorded high milk production. By analogy, ASHITABA could be used with mastitis or low milk production after delivery.
ASHITABA harmonizes the Spleen and Stomach.
ASHITABA harmonizes the Spleen and Stomach. It helps to balance the Earth element. There is a patient in Texas that has Insulin- Dependent Diabetes that is currently taking the herb. He says that he now has to use less Insulin because his blood sugar no longer spikes with attacks of Hyperglycemia. Another Diabetes patient in Japan took ASHITABA for six months and his blood sugar level dropped from 400 mg./dL to 150 mg./dL.
Dr. Kimie Baba
Dr. Kimi Baba at Osaka University School of Pharmacy has published a paper showing the decrease of the rate of acid production in the stomach with ASHITABA. In her paper she also showed a decrease in the severity of stress related to stomach ulcers. The extract of Hachi Jo Island’s ASHITABA also exhibited an anti-bacterial action.
CHALCONEs are the active factors in Angelica Keiskei Koidzumi. The two that are in ASHITABA are known as Xanthoangelol, Xanthoangelol-E and 4- Hydrooxyderricin. These were discovered by Dr. Kimie Baba. These factors are found only in this strain of ASHITABA from the Island of Hachi Jo and are derived from the yellowish liquid extract of the leaves and stems. This differentiates it from any other strain of ASHITABA from China, Taiwan, Korea.
Research in Japan has shown that ASHITABA has anti- viral properties. At a 1993 Pharmacology Forum in Japan, it was reported that ASHITABA demonstrated anti-HIV activity.
CHALCONE Anti-Cancer Inductors
ASHITABA contains a special kind of yellow sap which called CHALCONEs that are unique to this strain of Angelica specie. It is these CHALCONEs that are considered as the active ingredients that gives rise to ASHITABA's use as a diuretic, laxative, and aid to good metabolism.
ASHITABA also contains B 12, which is normally produced in animals and not plants. It is this uniqueness that places ASHITABA in the same category as marine products such as marine algae instead of other land based green plants. Vitamin B12 has been recognized for its ability to promote the production of blood cells, increase attention span and concentration, increase the production of growth hormone, and promote the immune system so that it can fight off serious disorder; such as cancer.
ASHITABA is recommended for all men and women of all ages, especially has been used for treating the following disorders:
Improve immunity systems
Gl tract disorders, Acute gastritis, chronic gastritis.
Hlorhydria, stomach cancer, duodenal ulcer.
Descensus ventriculi, gastric atoonia, chronic enteritis.
Carcinoma and Melanoma.
Chronic hepatitis, Blood Cleansing.
Diabetics and Insulin Diabetic dependent.
Hyperglycemia, Normalising of Sugar Level in the Blood.
Asthma and common colds.
Cell reproduction, Cell Revival.
High blood pressure, Vascular augmentation.
Anemia.
Excellent anti-oxidant
Chronic Fatigue Hangover.
Increase in Production of sperm.
Shoulder Stiffness.
Laxative, Diuretic, Neurosis.
Hemorrhoids.
Relieving of menopause and PMS symptoms.
Ageing of skin, beautiful skin complexion.
Anaemia and PMS Symptoms Research in China
Famous Researchers discussed dong quai, a traditional medicine root popular among women in Chinese women. Very significant amounts of Vitamin B12 found in the root, and are beneficial for anaemia and PMS symptoms which can include breast tenderness, bloating, sleep disturbances and irritability.Cancer Research and ASHITABA
Dr. Toru Okuyama, Meiji University, College of Pharmacy
Dr. Toru Okuyama tested Hachi Jo ASHITABA on mice with tobacco- induced lung cancer and skin melanomas. In this six month study the skin cancer mice were given an external application of the ASHITABA extract. The article stated that the cancer was controled-with this therapy. In the tobacco- induced lung cancer the mice were given the extract of ASHITABA in fluid and food form. The article stated that the lung cancer progression stopped with the oral ASHITABA therapy. The Active Factors in ASHITABA
Types of Angelica
The Angelica Family has a history as a medicinal herb and health food since ancient times in both China and Japan. In Mainland China and Taiwan the root of the Angelica Senesis has been popular for thousands of years and is frequently called the "Woman's Ginseng." Japanese ASHITABA, has an anti- viral property that is not present in Dang Gui (Tang Kuei). The Japanese ASHITABA extract is a gentler medicine that can be taken frequently and at bed time without the stimulating effect that Dang Quei has, especially on women. Because it is gentler, it can be tolerated better by peri- menopausal women.
Selasa, 14 September 2010
Senin, 13 September 2010
Minggu, 12 September 2010
Ashitaba Plant
The Ashitaba plant, also called don qui, is native to the Japanese island of Hachijo. Scientifically, the herb is called Angelica keiskei, which is derived form the Latin word "Angel," because of its mystical, highly praised effects. Find out more about the history of this popular plant and its many uses.
Characteristics of the Ashitaba
The Ashitaba is a perennial plant, which belongs to the Apiaceae family. The fragrant herb is smooth and hollow, with tall stems that hold bunches of white flowers. The seeds of it are sold in catalogs and online, esteemed by gardeners eager to experience the medicinal benefits and beautify common pots or gardens with the plant.
History of the Ashitaba Plant
The Ashitaba plant has been cherished for centuries in the Orient. The oldest recorded uses of the herb appear in a Chinese book written by Dr. Lee, who was believed to have lived from 1518 to 1593 A.D. The same book was copied into other languages, such as English, German, Latin and Russian.
Herbal Uses for the Ashitaba Plant
American herbalists use the Ashitaba as an edible medicine. The leaves and roots are considered a valuable diuretic, laxative and longevity herb, which is thought to promote wellness by boosting the body's immune system. The following are disorders treated with Ashitaba:
Other herbal uses of the Ashitaba plant encompass woman's symptoms related to menopause and menstruation. The active compounds in the herb are thought to strengthen the reproductive organs and assist with endometriosis. In addition, woman with PMS, hot flashes and headaches may find relief with herbal supplements containing Ashitaba.
Due to the blood purifying properties of the Ashitaba plant, it may also be useful for treating liver conditions, though these theories are being tested.
Properties of the Ashitaba Herb
Ashitaba is abundant in chlorophyll, which is shown to reduce the risk of cancer. The antioxidant properties in the plant make it beneficial for fighting free radicals (damaging molecules that promote aging, destroy tissues and promote disease in the body). Due to the plant's rich content of chlorophyll, B12 and antioxidants, it is recognized as a favorable herb for fighting disease and encouraging overall health. The youthful appearance of the Hachijo islanders is attributed to the consumption of the herb, which appeals to an array of individuals who may not otherwise have an interest in herbs and alternative remedies.
Safety and Uses for Ashitaba
Chinese herbalists extract healing substances from the Ashitaba plant by boiling it or soaking it in wine. When the root is removed, it can be taken as an oral medicine. It is also available in tablet, capsule, tea and raw root forms as well as an ingredient in cosmetics. While it is safe in moderation, it may interact with some medications. If you are purchasing an herbal product over-the-counter, be sure the product is of good quality. Because herbal remedies are not evaluated by the food and drug administration (FDA), you should always talk to a medical professional before experimenting with Ashitaba plant supplements.
The Ashitaba plant, also called don qui, is native to the Japanese island of Hachijo. Scientifically, the herb is called Angelica keiskei, which is derived form the Latin word "Angel," because of its mystical, highly praised effects. Find out more about the history of this popular plant and its many uses.
Characteristics of the Ashitaba
The Ashitaba is a perennial plant, which belongs to the Apiaceae family. The fragrant herb is smooth and hollow, with tall stems that hold bunches of white flowers. The seeds of it are sold in catalogs and online, esteemed by gardeners eager to experience the medicinal benefits and beautify common pots or gardens with the plant.
History of the Ashitaba Plant
The Ashitaba plant has been cherished for centuries in the Orient. The oldest recorded uses of the herb appear in a Chinese book written by Dr. Lee, who was believed to have lived from 1518 to 1593 A.D. The same book was copied into other languages, such as English, German, Latin and Russian.
Herbal Uses for the Ashitaba Plant
American herbalists use the Ashitaba as an edible medicine. The leaves and roots are considered a valuable diuretic, laxative and longevity herb, which is thought to promote wellness by boosting the body's immune system. The following are disorders treated with Ashitaba:
- Chronic gastritis
- Stomach cancer
- High blood pressure
- Anemia
- Carcinoma
- Ulcers
- Chronic fatigue
- Diabetes
- Muscle aches and pains
- Cold symptoms
- Hemorrhoids
- Aging
Other herbal uses of the Ashitaba plant encompass woman's symptoms related to menopause and menstruation. The active compounds in the herb are thought to strengthen the reproductive organs and assist with endometriosis. In addition, woman with PMS, hot flashes and headaches may find relief with herbal supplements containing Ashitaba.
Due to the blood purifying properties of the Ashitaba plant, it may also be useful for treating liver conditions, though these theories are being tested.
Properties of the Ashitaba Herb
Ashitaba is abundant in chlorophyll, which is shown to reduce the risk of cancer. The antioxidant properties in the plant make it beneficial for fighting free radicals (damaging molecules that promote aging, destroy tissues and promote disease in the body). Due to the plant's rich content of chlorophyll, B12 and antioxidants, it is recognized as a favorable herb for fighting disease and encouraging overall health. The youthful appearance of the Hachijo islanders is attributed to the consumption of the herb, which appeals to an array of individuals who may not otherwise have an interest in herbs and alternative remedies.
Safety and Uses for Ashitaba
Chinese herbalists extract healing substances from the Ashitaba plant by boiling it or soaking it in wine. When the root is removed, it can be taken as an oral medicine. It is also available in tablet, capsule, tea and raw root forms as well as an ingredient in cosmetics. While it is safe in moderation, it may interact with some medications. If you are purchasing an herbal product over-the-counter, be sure the product is of good quality. Because herbal remedies are not evaluated by the food and drug administration (FDA), you should always talk to a medical professional before experimenting with Ashitaba plant supplements.
Related Scientific Studies on Ashitaba Varieties
Anti-tumor-promotion by principles obtained from Angelica keiskei.
Okuyama T, Takata M, Takayasu J, Hasegawa T, Tokuda H, Nishino A, Nishino H, Iwashima A.
Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy, Tokyo, Japan.
Potent anti-tumor promoter activity has been found in the nonpolar extracts of the root of "Ashita-Ba", Angelica keiskei Koidz. (Umbelliferae), which is eaten as a vegetable in Japan. From this active fraction, two angular furanocoumarins, archangelicin (1) and 8(S),9(R)-9-angeloyloxy-8,9-dihydrooroselol (2), three linear furanocoumarins, psoralen (3), bergapten (4) and xanthotoxin (5), and three chalcones, 4-hydroxyderricin (6), xanthoangelol (7) and a novel chalcone named ashitaba-chalcone (8), were isolated. Among these compounds, two angular type furanocoumarins, 1 and 2, and three chalcones, 6-8, suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated 32Pi-incorporation into phospholipids of cultured cells, whereas coumarins 3-5 were less effective. In addition, chalcones 6 and 7 were proved to have anti-tumor-promoting activity in mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) plus TPA. Since chalcones 6 and 7 showed calmodulin-interacting property, both chalcones may reveal anti-tumor-promoting activity via the modulation of calmodulin involved systems. These chalcones may be useful to develop the effective method for cancer prevention. Chem Pharm Bull (Tokyo) 1991 Jun;39(6):1604-5
Antibacterial activity of two chalcones, xanthoangelol and 4-hydroxyderricin, isolated from the root of Angelica keiskei KOIDZUMI.
Inamori Y, Baba K, Tsujibo H, Taniguchi M, Nakata K, Kozawa M.
Osaka University of Pharmaceutical Sciences, Japan.
Two chalcones, xanthoangelol (I) and 4-hydroxyderricin (II), isolated from the root of Angelica keiskei KOIDZUMI (Umbelliferae) showed antibacterial activity against gram-positive pathogenic bacteria. The activity of I on Micrococcus luteus IFO-12708 (minimum inhibitory concentration (MIC), 0.76 microgram/ml) was the same potency as that of gentamicin, which is used as a standard. Although the activity of both chalcones on plant-pathogenic bacteria was lower than that of streptomycin sulfate, used as a positive control, they also exhibited growth-inhibitory effects. The antibacterial activity of I isolated from Angelica keiskei KOIDZUMI is being reported here for the first time. The growth-inhibitory effect of II on plant-pathogenic bacteria is also reported for the first time in this paper. Pharmacol Ther 1991 Dec;52(3):331-63
Angelicins, Angular Analogs Of Psoralens: Chemistry, Photochemical, Photobiological And Phototherapeutic Properties.
Bordin F, Dall'Acqua F, Guiotto A.
Department of Pharmaceutical Science of Padua University, Centro di Studio sulla Chimica del Farmaco e dei Prodotti Biologicamente Attivi del C.N.R., Italy.
Angelicin and some of its derivatives are naturally occuring compounds which show interesting photobiological properties. In this review various aspects of angelicin and its derivatives have been reported. The natural occurrence and the chemical synthesis both of naturally occurring and synthetic angelicins have been reviewed. Photochemical and photophysical properties of angelicins have been considered with particular reference to the capacity to generate active forms of oxygen, photoreactions with nucleic acids, proteins and unsaturated fatty acids. Photobiological effects have been considered: skin phototoxicity, antiproliferative effects, genotoxicity, ability to induce hemolysis in erythrocytes, inactivation of prokaryotic and eukaryotic microorganism and of viruses. The ability of some angelicins to induce photocarcinogenesis has been reviewed as well as in the activity as photochemotherapeutic agents. J Altern Complement Med 2000 Dec;6(6):557-9
The Effect Of A Traditional Chinese Prescription For A Case Of Lung Carcinoma.
Kamei T, Kumano H, Iwata K, Nariai Y, Matsumoto T.
Shimane Institute of Health Science, Izumo, Japan. kamei@hanken.shimane-med.ac.jp
OBJECTIVE: To examine the effectiveness of Ninjin Yoei To (NYT; Ren-Shen-Yang-Rong-Tang in Chinese medicine; Kotaro Pharmaceutical Co., Ltd., Osaka, Japan), one of the traditional herbal medicines, against lung carcinoma. SETTING: The Nursing Center Himawari DESIGN, PATIENT, AND PREPARATION: The regular dosage of NYT (15 g/d) was prescribed for 7 weeks to one elderly patient with lung carcinoma. The daily standard dose of NYT is prepared from dried extract obtained from 12 crude natural substances, ginseng, cinnamon bark, Japanese angelica root, astragalus root, peony root, citrus unshiu peel, rehmannia root, polygala root, atractylodes rhizome, schisanda fruit, poria sclerotium, and glycyrrhiza. NYT is certified by the Japanese Ministry of Health and Welfare. RESULTS: The tumor marker levels (CEA and CA19-9) decreased and the scores of yin-yang and xu-shi inverted from negative and positive during 7 weeks. The patient's cough disappeared and her appetite recovered. CONCLUSION: NYT has a positive effect on life expectancy for patients with malignancy. The diagnostic scoring system in yin-yang and xu-shi and prescription of Chinese herb may be available to gain control over a patient's health.
Biorheology 2003;40(1-3):395-9
Effect Of Angelica On The Expressional Changes Of Cytokines In Endothelial Cells Induced By Hyperlipidemic Serum.
Jing-Ping OY, Baohua W, Yongming L, Lei W, Jingwei Y.
Department of Pathophysiology, Medical College of Wuhan University, Wuhan, 430071, P.R. China. hybs@public.wh.hb.cn
The aim of this article was to examine the protective effect of Chinese traditional medicine angelica on human umbilical vein endothelial cells (HUVECs, ECV304) from injury induced by hyperlipidemic serum (HLS) and to study the underlying mechanism. Spectrophotometer and immunocytochemical methods were used to detect the content of nitric oxide (NO) in suspension and expression of intercellular adhesion molecule-1 (ICAM-1), transforming growth factor beta1 (TGFbeta1), basic fibroblast growth factor (bFGF) on the cell surface, respectively. After incubated with 50 microl/ml HLS for 24 hours, expression of ICAM-1 and bFGF in ECs was significantly increased, while expression of TGFbeta1 and the release of NO from ECs were significantly decreased. All these effect of HLS on ECs can be reversed by angelica significantly. The above effect of angelica may be related to its anti-atherosclerotic action. Our findings provided experimental basement for the clinical application of angelica to prevent the development of atherosclerosis. Clin Hemorheol Microcirc 2001;24(3):201-5
Effects Of An Angelica Extract On Human Erythrocyte Aggregation, Deformation And Osmotic Fragility.
Wang X, Wei L, Ouyang JP, Muller S, Gentils M, Cauchois G, Stoltz JF.
Group Cell and Tissue Mechanics and Engineering, LEMTA - UMR 7563 CNRS/INPL/UHP, 54500 Vandoeuvre-les-Nancy, France. xwang@ensem.inpl-nancy.fr
In Chinese traditional medicine, angelica is widely used for its known clinical effects of ameliorating blood microcirculation. But the mechanism of these beneficial effects still remains unclear. In this work the rheological behaviour of human erythrocytes treated by angelica was studied in vitro. Normal RBCs incubated with an angelica extract at different concentrations (5, 10 or 20 mg/ml) for 60 min at 37 degrees C and then their aggregation, deformation and osmotic fragility were measured with different recently developed optical techniques, namely Erythroaggregometer (Regulest, Florange, France), LORCA (Mechatronics, Amsterdam) and Fragilimeter (Regulest, Florange, France). Experimental results show that angelica (20 mg/ml) significantly decreased normal RBCs' aggregation speed (p<0.01) and could inhibit the hyperaggregability caused by dextran 500. However, the strength of normal RBCs aggregates were not influenced by angelica. When a calcium ionophore A23187 (1.9 microM) was used to harden cell membrane, angelica (20 mg/ml) could significantly (p<0.01) protect erythrocytes against the loss of their deformability even it had no effects on normal RBCs deformation. Finally angelica (5 and 10 mg/ml) decreased significantly (p<0.01) normal RBCs osmotic fragility. In conclusion angelica plays a rheologically active role on human erythrocytes, and this study suggests a possible mechanism for angelica's positive effects against certain cardiovascular diseases.
Arch Pharm Res 1991 Mar;14(1):87-92
Pharmacological Activities Of Water Extracts Of Umbelliferae Plants.
Kim CM, Heo MY, Kim HP, Sin KS, Pachaly P.
College of Pharmacy, Kangweon National Univ., Chuncheon, Korea.
In order to evaluate the pharmacological activities of Chinese medicine, nine Umbelliferae plants were selected and their restoring activity against dexamethasone-induced disorders, liver protective activity, antimicrobial activity, anti-inflammatory activity and antimutagenic activity were tested and compared. Angelica dahurica. Angelica acutiloba and Ostericum koreanum showed various activities in these tests at the dose used in this study.
Anti-tumor-promotion by principles obtained from Angelica keiskei.
Okuyama T, Takata M, Takayasu J, Hasegawa T, Tokuda H, Nishino A, Nishino H, Iwashima A.
Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy, Tokyo, Japan.
Potent anti-tumor promoter activity has been found in the nonpolar extracts of the root of "Ashita-Ba", Angelica keiskei Koidz. (Umbelliferae), which is eaten as a vegetable in Japan. From this active fraction, two angular furanocoumarins, archangelicin (1) and 8(S),9(R)-9-angeloyloxy-8,9-dihydrooroselol (2), three linear furanocoumarins, psoralen (3), bergapten (4) and xanthotoxin (5), and three chalcones, 4-hydroxyderricin (6), xanthoangelol (7) and a novel chalcone named ashitaba-chalcone (8), were isolated. Among these compounds, two angular type furanocoumarins, 1 and 2, and three chalcones, 6-8, suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated 32Pi-incorporation into phospholipids of cultured cells, whereas coumarins 3-5 were less effective. In addition, chalcones 6 and 7 were proved to have anti-tumor-promoting activity in mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) plus TPA. Since chalcones 6 and 7 showed calmodulin-interacting property, both chalcones may reveal anti-tumor-promoting activity via the modulation of calmodulin involved systems. These chalcones may be useful to develop the effective method for cancer prevention. Chem Pharm Bull (Tokyo) 1991 Jun;39(6):1604-5
Antibacterial activity of two chalcones, xanthoangelol and 4-hydroxyderricin, isolated from the root of Angelica keiskei KOIDZUMI.
Inamori Y, Baba K, Tsujibo H, Taniguchi M, Nakata K, Kozawa M.
Osaka University of Pharmaceutical Sciences, Japan.
Two chalcones, xanthoangelol (I) and 4-hydroxyderricin (II), isolated from the root of Angelica keiskei KOIDZUMI (Umbelliferae) showed antibacterial activity against gram-positive pathogenic bacteria. The activity of I on Micrococcus luteus IFO-12708 (minimum inhibitory concentration (MIC), 0.76 microgram/ml) was the same potency as that of gentamicin, which is used as a standard. Although the activity of both chalcones on plant-pathogenic bacteria was lower than that of streptomycin sulfate, used as a positive control, they also exhibited growth-inhibitory effects. The antibacterial activity of I isolated from Angelica keiskei KOIDZUMI is being reported here for the first time. The growth-inhibitory effect of II on plant-pathogenic bacteria is also reported for the first time in this paper. Pharmacol Ther 1991 Dec;52(3):331-63
Angelicins, Angular Analogs Of Psoralens: Chemistry, Photochemical, Photobiological And Phototherapeutic Properties.
Bordin F, Dall'Acqua F, Guiotto A.
Department of Pharmaceutical Science of Padua University, Centro di Studio sulla Chimica del Farmaco e dei Prodotti Biologicamente Attivi del C.N.R., Italy.
Angelicin and some of its derivatives are naturally occuring compounds which show interesting photobiological properties. In this review various aspects of angelicin and its derivatives have been reported. The natural occurrence and the chemical synthesis both of naturally occurring and synthetic angelicins have been reviewed. Photochemical and photophysical properties of angelicins have been considered with particular reference to the capacity to generate active forms of oxygen, photoreactions with nucleic acids, proteins and unsaturated fatty acids. Photobiological effects have been considered: skin phototoxicity, antiproliferative effects, genotoxicity, ability to induce hemolysis in erythrocytes, inactivation of prokaryotic and eukaryotic microorganism and of viruses. The ability of some angelicins to induce photocarcinogenesis has been reviewed as well as in the activity as photochemotherapeutic agents. J Altern Complement Med 2000 Dec;6(6):557-9
The Effect Of A Traditional Chinese Prescription For A Case Of Lung Carcinoma.
Kamei T, Kumano H, Iwata K, Nariai Y, Matsumoto T.
Shimane Institute of Health Science, Izumo, Japan. kamei@hanken.shimane-med.ac.jp
OBJECTIVE: To examine the effectiveness of Ninjin Yoei To (NYT; Ren-Shen-Yang-Rong-Tang in Chinese medicine; Kotaro Pharmaceutical Co., Ltd., Osaka, Japan), one of the traditional herbal medicines, against lung carcinoma. SETTING: The Nursing Center Himawari DESIGN, PATIENT, AND PREPARATION: The regular dosage of NYT (15 g/d) was prescribed for 7 weeks to one elderly patient with lung carcinoma. The daily standard dose of NYT is prepared from dried extract obtained from 12 crude natural substances, ginseng, cinnamon bark, Japanese angelica root, astragalus root, peony root, citrus unshiu peel, rehmannia root, polygala root, atractylodes rhizome, schisanda fruit, poria sclerotium, and glycyrrhiza. NYT is certified by the Japanese Ministry of Health and Welfare. RESULTS: The tumor marker levels (CEA and CA19-9) decreased and the scores of yin-yang and xu-shi inverted from negative and positive during 7 weeks. The patient's cough disappeared and her appetite recovered. CONCLUSION: NYT has a positive effect on life expectancy for patients with malignancy. The diagnostic scoring system in yin-yang and xu-shi and prescription of Chinese herb may be available to gain control over a patient's health.
Biorheology 2003;40(1-3):395-9
Effect Of Angelica On The Expressional Changes Of Cytokines In Endothelial Cells Induced By Hyperlipidemic Serum.
Jing-Ping OY, Baohua W, Yongming L, Lei W, Jingwei Y.
Department of Pathophysiology, Medical College of Wuhan University, Wuhan, 430071, P.R. China. hybs@public.wh.hb.cn
The aim of this article was to examine the protective effect of Chinese traditional medicine angelica on human umbilical vein endothelial cells (HUVECs, ECV304) from injury induced by hyperlipidemic serum (HLS) and to study the underlying mechanism. Spectrophotometer and immunocytochemical methods were used to detect the content of nitric oxide (NO) in suspension and expression of intercellular adhesion molecule-1 (ICAM-1), transforming growth factor beta1 (TGFbeta1), basic fibroblast growth factor (bFGF) on the cell surface, respectively. After incubated with 50 microl/ml HLS for 24 hours, expression of ICAM-1 and bFGF in ECs was significantly increased, while expression of TGFbeta1 and the release of NO from ECs were significantly decreased. All these effect of HLS on ECs can be reversed by angelica significantly. The above effect of angelica may be related to its anti-atherosclerotic action. Our findings provided experimental basement for the clinical application of angelica to prevent the development of atherosclerosis. Clin Hemorheol Microcirc 2001;24(3):201-5
Effects Of An Angelica Extract On Human Erythrocyte Aggregation, Deformation And Osmotic Fragility.
Wang X, Wei L, Ouyang JP, Muller S, Gentils M, Cauchois G, Stoltz JF.
Group Cell and Tissue Mechanics and Engineering, LEMTA - UMR 7563 CNRS/INPL/UHP, 54500 Vandoeuvre-les-Nancy, France. xwang@ensem.inpl-nancy.fr
In Chinese traditional medicine, angelica is widely used for its known clinical effects of ameliorating blood microcirculation. But the mechanism of these beneficial effects still remains unclear. In this work the rheological behaviour of human erythrocytes treated by angelica was studied in vitro. Normal RBCs incubated with an angelica extract at different concentrations (5, 10 or 20 mg/ml) for 60 min at 37 degrees C and then their aggregation, deformation and osmotic fragility were measured with different recently developed optical techniques, namely Erythroaggregometer (Regulest, Florange, France), LORCA (Mechatronics, Amsterdam) and Fragilimeter (Regulest, Florange, France). Experimental results show that angelica (20 mg/ml) significantly decreased normal RBCs' aggregation speed (p<0.01) and could inhibit the hyperaggregability caused by dextran 500. However, the strength of normal RBCs aggregates were not influenced by angelica. When a calcium ionophore A23187 (1.9 microM) was used to harden cell membrane, angelica (20 mg/ml) could significantly (p<0.01) protect erythrocytes against the loss of their deformability even it had no effects on normal RBCs deformation. Finally angelica (5 and 10 mg/ml) decreased significantly (p<0.01) normal RBCs osmotic fragility. In conclusion angelica plays a rheologically active role on human erythrocytes, and this study suggests a possible mechanism for angelica's positive effects against certain cardiovascular diseases.
Arch Pharm Res 1991 Mar;14(1):87-92
Pharmacological Activities Of Water Extracts Of Umbelliferae Plants.
Kim CM, Heo MY, Kim HP, Sin KS, Pachaly P.
College of Pharmacy, Kangweon National Univ., Chuncheon, Korea.
In order to evaluate the pharmacological activities of Chinese medicine, nine Umbelliferae plants were selected and their restoring activity against dexamethasone-induced disorders, liver protective activity, antimicrobial activity, anti-inflammatory activity and antimutagenic activity were tested and compared. Angelica dahurica. Angelica acutiloba and Ostericum koreanum showed various activities in these tests at the dose used in this study.
Research on the Effects of Ashitaba, Angelica Keiskei Koidzumi
By Dr. Kevin Lance Jones, L.Ac., O.M.D.
Little is known about the world of Herbal Medicine. Of all the plant species in the world, only five percent (5%) have been cataloged. Of that five percent that have been cataloged, a full one quarter (1/4) or tweet - five percent (25%) have medicinal qualities. There is the example of Taxol, an anti-uterine cancer drug that is derived from the bark of the Yu tree.
Another shinning example of a newly discovered herbal medicine is ASHITABA. Its name literally translates to "Early Growth" in Japanese. It was named so because of its ability to grow very fast and exhibit a strong Qi or energetic life force.
What is Ashitaba?
Ashitaba is indigenous to a small area called the Seven Islands of Izu. It is a herbaceous plant that grows year round. This greenish yellow vegetable has been mentioned in many ancient Japanese Medical Writings. It has been consumed as a vegetable and medicine for many hundreds of years by the local island herbalists. Ashitaba contains a variety of vitamins, minerals, proteins and plant fiber. This powerful strain of Angelica was unknown until recently. Only a few islanders knew of this herb and kept it a guarded secret.With the coming of the information age, news of this healing plant began to reach beyond the Seven Islands of Izu. The leaves and stems are used to extract a yellowish liquid from the plant.
The Properties and Therapeutic Uses of Ashitaba
In this section I will endeavor to explain the therapeutic actions of Angelica Keiskei Koidzumi or Ashitaba in terms of Traditional Chinese Medicine as practiced currently in the People's Republic of China. One of the fundamental actions of Ashitaba is that it is great at activating Qi and Xue (Blood). The application for this is apparent in the treatment in the menstrual problems. It removes stagnation in the uterus, which will help with many menstrual difficulties. It also increases blood flow (activates Qi and Blood). This herb, which can be used by it self alone, increases Kidney Yin and Yang Qi.
The increase of the Kidney Yang Qi will act as a diuretic and increase the urine output. In Japan, Ashitaba is used to treat hypertension. As a diuretic it has no side effects such as western medicines frequently have. It increases the libido (sex drive) for those persons with Kidney Yang Xu (deficiency). In terms of the increase in Kidney Yin Xu (deficiency), this herb is wonderful in treating the problem of Peri- menopause. With a Kidney Yin Xu (deficiency) one of the cardinal symptoms in women is irregular or no menstruation. The usual four to six years of peri menopause that women in their middle forties to early fifties in age experience could be made much more comfortable with the use of Ashitaba. Because this herb warms the uterus, it is very useful in treating menstrual cramps and pain, regardless of the age of the patient.
Ashitaba is a useful Lactagogue, that is, an agent which induces the secretion of mother's milk. There is anecdotal evidence from Japan of a cow that was fed Ashitaba and had record milk production. By analogy, Ashitaba could be used with mastitis or low milk production after delivery.
Ashitaba harmonizes the Spleen and Stomach. It helps to balance the Earth element. There is a patient in Texas that has Insulin- Dependent Diabetes that is currently taking the herb. He says that he now has to use less Insulin because his blood sugar no longer spikes with attacks of Hyperglycemia. Another Diabetes patient in Japan took Ashitaba for six months and his blood sugar level droped from 400 mg./dL to 150 mg./dL. Dr. Baba at Osaka University School of Pharmacy has published a paper showing the decrease of the rate of acid production in the stomach with Ashitaba. In her paper he also showed a decrease in the severity of stress related to stomach ulcers. The extract of Angelica Keiskei Koidzumi also exhibited an anti-bacterial action.
Research in Japan has shown that Ashitaba has anti- viral properties. At a 1993 Pharmacology Forum in Japan, it was reported that A a demonstrated antiHIV activity.
The Active Factors in Ashitaba
Chalcones are the active factors in Angelica Keiskei Koidzumi. The two that are in Ashitaba are known as Xanthoangelol and 4- Hydrooxyderricin. These were discovered by Dr. Baba. These factors are found only in this strain of Angelica and are derived from the yellowish liquid extract of the leaves and stems. This differentiates it from any other strain of Angelica.
Types of Angelica
The Angelica Family has a history as a medicinal herb and health food since ancient times in both China and Japan. In Mainland China and Taiwan the root of the Angelica Senesis has been popular for thousands of years and is frequently called the "Woman's Ginseng." Ashitaba, has an anti- viral property that is not present in Dang Gui (Tang Kuei). The Ashitaba extract is a gentler medicine that can be taken frequently and at bed time without the stimulating effect that Dang Gui has, especially on women. Because it is gentler, it can be tolerated better by peri- menopausal women.
Cancer Research and Ashitaba
Dr. Toru Okuyama at Meiji University, College of Pharmacy tested Ashitaba on mice with tobacco- induced lung cancer and skin melanomas. In this six month study the skin cancer mice were given an external application of the Ashitaba extract. The article stated that the cancer was controled-with this therapy. In the tobacco- induced lung cancer the mice were given the extract of Ashitaba in fluid and food form. The article stated that the lung cancer progression stopped with the oral Ashitaba therapy.
By Dr. Kevin Lance Jones, L.Ac., O.M.D.
Little is known about the world of Herbal Medicine. Of all the plant species in the world, only five percent (5%) have been cataloged. Of that five percent that have been cataloged, a full one quarter (1/4) or tweet - five percent (25%) have medicinal qualities. There is the example of Taxol, an anti-uterine cancer drug that is derived from the bark of the Yu tree.
Another shinning example of a newly discovered herbal medicine is ASHITABA. Its name literally translates to "Early Growth" in Japanese. It was named so because of its ability to grow very fast and exhibit a strong Qi or energetic life force.
What is Ashitaba?
Ashitaba is indigenous to a small area called the Seven Islands of Izu. It is a herbaceous plant that grows year round. This greenish yellow vegetable has been mentioned in many ancient Japanese Medical Writings. It has been consumed as a vegetable and medicine for many hundreds of years by the local island herbalists. Ashitaba contains a variety of vitamins, minerals, proteins and plant fiber. This powerful strain of Angelica was unknown until recently. Only a few islanders knew of this herb and kept it a guarded secret.With the coming of the information age, news of this healing plant began to reach beyond the Seven Islands of Izu. The leaves and stems are used to extract a yellowish liquid from the plant.
The Properties and Therapeutic Uses of Ashitaba
In this section I will endeavor to explain the therapeutic actions of Angelica Keiskei Koidzumi or Ashitaba in terms of Traditional Chinese Medicine as practiced currently in the People's Republic of China. One of the fundamental actions of Ashitaba is that it is great at activating Qi and Xue (Blood). The application for this is apparent in the treatment in the menstrual problems. It removes stagnation in the uterus, which will help with many menstrual difficulties. It also increases blood flow (activates Qi and Blood). This herb, which can be used by it self alone, increases Kidney Yin and Yang Qi.
The increase of the Kidney Yang Qi will act as a diuretic and increase the urine output. In Japan, Ashitaba is used to treat hypertension. As a diuretic it has no side effects such as western medicines frequently have. It increases the libido (sex drive) for those persons with Kidney Yang Xu (deficiency). In terms of the increase in Kidney Yin Xu (deficiency), this herb is wonderful in treating the problem of Peri- menopause. With a Kidney Yin Xu (deficiency) one of the cardinal symptoms in women is irregular or no menstruation. The usual four to six years of peri menopause that women in their middle forties to early fifties in age experience could be made much more comfortable with the use of Ashitaba. Because this herb warms the uterus, it is very useful in treating menstrual cramps and pain, regardless of the age of the patient.
Ashitaba is a useful Lactagogue, that is, an agent which induces the secretion of mother's milk. There is anecdotal evidence from Japan of a cow that was fed Ashitaba and had record milk production. By analogy, Ashitaba could be used with mastitis or low milk production after delivery.
Ashitaba harmonizes the Spleen and Stomach. It helps to balance the Earth element. There is a patient in Texas that has Insulin- Dependent Diabetes that is currently taking the herb. He says that he now has to use less Insulin because his blood sugar no longer spikes with attacks of Hyperglycemia. Another Diabetes patient in Japan took Ashitaba for six months and his blood sugar level droped from 400 mg./dL to 150 mg./dL. Dr. Baba at Osaka University School of Pharmacy has published a paper showing the decrease of the rate of acid production in the stomach with Ashitaba. In her paper he also showed a decrease in the severity of stress related to stomach ulcers. The extract of Angelica Keiskei Koidzumi also exhibited an anti-bacterial action.
Research in Japan has shown that Ashitaba has anti- viral properties. At a 1993 Pharmacology Forum in Japan, it was reported that A a demonstrated antiHIV activity.
The Active Factors in Ashitaba
Chalcones are the active factors in Angelica Keiskei Koidzumi. The two that are in Ashitaba are known as Xanthoangelol and 4- Hydrooxyderricin. These were discovered by Dr. Baba. These factors are found only in this strain of Angelica and are derived from the yellowish liquid extract of the leaves and stems. This differentiates it from any other strain of Angelica.
Types of Angelica
The Angelica Family has a history as a medicinal herb and health food since ancient times in both China and Japan. In Mainland China and Taiwan the root of the Angelica Senesis has been popular for thousands of years and is frequently called the "Woman's Ginseng." Ashitaba, has an anti- viral property that is not present in Dang Gui (Tang Kuei). The Ashitaba extract is a gentler medicine that can be taken frequently and at bed time without the stimulating effect that Dang Gui has, especially on women. Because it is gentler, it can be tolerated better by peri- menopausal women.
Cancer Research and Ashitaba
Dr. Toru Okuyama at Meiji University, College of Pharmacy tested Ashitaba on mice with tobacco- induced lung cancer and skin melanomas. In this six month study the skin cancer mice were given an external application of the Ashitaba extract. The article stated that the cancer was controled-with this therapy. In the tobacco- induced lung cancer the mice were given the extract of Ashitaba in fluid and food form. The article stated that the lung cancer progression stopped with the oral Ashitaba therapy.
Ashitaba, A Medicinal Plant and Health Method
By Kazuo Hida, Medicinal Plant Specialist
ASHITABA (Tomorrow's leaf) has its origins on the Island of Hachijo where the warm tropical currents pass by on their way North to meet the cold Arctic waters of the Pacific. How did Ashitaba come by its name of tomorrow's leaf or weed. It was named for its ability to reproduce its green stem and leaf almost on a daily basis.
Asitaba's scientific name, Angelica keiskei Koidzumi, comes from the Latin name for Angel, and because of its godly effects that have given it its notoriety. The population of Hachijo Island are known for their longevity, living until the ripe old age of 90's. When all aspects of their life style were analyzed the determination was that the consumption of ashitaba was a heavy contribution to the extended lifetime. As more study was conducted on the composition of this special strain of angelica, ashitaba has been attracting more and more attention from the scientific community.
Medicinal Value of this plant
The oldest written record of the medicinal value of Ashitaba appears in a Chinese book listing the medicines that can be derived from grass. The book was first published during the Ming Dynasty and was written by Dr. Lee during his lifetime from 1518 to 1593 AD. This book was then transcribed into Latin, English, German, Russian and became internationally famous as a publication on Oriental Medicine. It was brought into Japan and presented to the Shogun by Razan Hayashi in 1606.
Green plants such as Ashitaba are the basis of our energy conversion life cycle. These green plants contain chlorophyll whth uses tho energy from the sun to convert carbon dioxide into oxygen and create a by-product, starch. Chlorophyll has shown an ability to be an anti-bacterial, aid in the production of blood, and an ability to help heal wounds.
Ashitaba, which contains high levels of chlorophyll, is actually a weed, and is used to existing under sever conditions such as high winds, rain, high salinity, and generally bad weather. However, it is actually these same conditions that train the ashitaba plant and build its constitution so that it can produce the unique by-products that can help keep the body and its functions in balance.
Ashitaba contains a yellow sap which contains chalcones that are unique to this strain of angelica. It is these chalcones that are considered as the active ingredients that give rise to ashitaba's use as a diuretic, laxative, and aid to good metabolism.
Ashitaba also contains B 12, which is normally produced in animals and not plants. It is this uniqueness that places ashitaba in the same category as marine products such as marine algae instead of other land based green plants. Vitamin B12 has been recognized for its ability to promote the production of blood cells, increase attention span and concentration, increase the production of growth hormone, and promote the immune system so that it can fight off serious disorder; such as cancer.
Ashitaba has also been used as a treatment for the following disorders:
Gl tract disorders:
Acute gastritis, Chronic gastritis, Chlorhydria, Stomach cancer, Duodenal ulcer, Descensus ventriculi, Gastric atoonia, and Chronic enteritis
Chronic hepatitis, Cell reproduction, Blood cleansing,
High blood pressure, Carcinoma, Vascular augmentation, Anemia,
Chronic fatigue hangover, Asthma, Common colds,
Production of sperm, Diabetes, Shoulder stiffness, Laxative
Diuretic, Neurosis, Hemorrhoids, Aging of skin
By Kazuo Hida, Medicinal Plant Specialist
ASHITABA (Tomorrow's leaf) has its origins on the Island of Hachijo where the warm tropical currents pass by on their way North to meet the cold Arctic waters of the Pacific. How did Ashitaba come by its name of tomorrow's leaf or weed. It was named for its ability to reproduce its green stem and leaf almost on a daily basis.
Asitaba's scientific name, Angelica keiskei Koidzumi, comes from the Latin name for Angel, and because of its godly effects that have given it its notoriety. The population of Hachijo Island are known for their longevity, living until the ripe old age of 90's. When all aspects of their life style were analyzed the determination was that the consumption of ashitaba was a heavy contribution to the extended lifetime. As more study was conducted on the composition of this special strain of angelica, ashitaba has been attracting more and more attention from the scientific community.
Medicinal Value of this plant
The oldest written record of the medicinal value of Ashitaba appears in a Chinese book listing the medicines that can be derived from grass. The book was first published during the Ming Dynasty and was written by Dr. Lee during his lifetime from 1518 to 1593 AD. This book was then transcribed into Latin, English, German, Russian and became internationally famous as a publication on Oriental Medicine. It was brought into Japan and presented to the Shogun by Razan Hayashi in 1606.
Green plants such as Ashitaba are the basis of our energy conversion life cycle. These green plants contain chlorophyll whth uses tho energy from the sun to convert carbon dioxide into oxygen and create a by-product, starch. Chlorophyll has shown an ability to be an anti-bacterial, aid in the production of blood, and an ability to help heal wounds.
Ashitaba, which contains high levels of chlorophyll, is actually a weed, and is used to existing under sever conditions such as high winds, rain, high salinity, and generally bad weather. However, it is actually these same conditions that train the ashitaba plant and build its constitution so that it can produce the unique by-products that can help keep the body and its functions in balance.
Ashitaba contains a yellow sap which contains chalcones that are unique to this strain of angelica. It is these chalcones that are considered as the active ingredients that give rise to ashitaba's use as a diuretic, laxative, and aid to good metabolism.
Ashitaba also contains B 12, which is normally produced in animals and not plants. It is this uniqueness that places ashitaba in the same category as marine products such as marine algae instead of other land based green plants. Vitamin B12 has been recognized for its ability to promote the production of blood cells, increase attention span and concentration, increase the production of growth hormone, and promote the immune system so that it can fight off serious disorder; such as cancer.
Ashitaba has also been used as a treatment for the following disorders:
Gl tract disorders:
Acute gastritis, Chronic gastritis, Chlorhydria, Stomach cancer, Duodenal ulcer, Descensus ventriculi, Gastric atoonia, and Chronic enteritis
Chronic hepatitis, Cell reproduction, Blood cleansing,
High blood pressure, Carcinoma, Vascular augmentation, Anemia,
Chronic fatigue hangover, Asthma, Common colds,
Production of sperm, Diabetes, Shoulder stiffness, Laxative
Diuretic, Neurosis, Hemorrhoids, Aging of skin
Research on Ashitaba and Cancer
In vitro induction of the anticarcinogenic marker enzyme, quinone reductase, in human hepatoma cells by food extracts.
Hashimoto K, Kawamata S, Usui N, Tanaka A, Uda Y. Cancer Lett. 2002 Jun 6;180(1):1-5.
Anti-tumor-promotion by principles obtained from Angelica keiskei. Okuyama T, Takata M, Takayasu J, Hasegawa T, Tokuda H, Nishino A, Nishino H, Iwashima A. Planta Med. 1991 Jun;57(3):242-6.
Potent antimitotic and cell growth inhibitory properties of substituted chalcones, S. Ducki, R. Forrest, et al.,. Med. Chem. Lett., 1998, 8, 1051.
Ashitaba Helps to Inhibit Cancer: Linked Parallel Synthesis and MTT Bioassay Screening of Substituted Chalcones, N. J. Lawrence, D. Rennison, A. T. et al., Chem., 2001, 3, in press.
The Interaction of Chalcones with Tubulin, N. J. Lawrence, A. T. McGown, S. Ducki and J. A. Hadfield, Anticancer Drug Design, 2000, 15, 135.
Effect of naturally occurring coumarins on the formation of epidermal DNA adducts and skin tumors induced by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in SENCAR mice. Cai Y, Kleiner H, Johnston D, Dubowski A, Bostic S, Ivie W, DiGiovanni J.
Isobavachalcone, a Chalcone Constituent of Angelica keiskei, Induces Apoptosis in Neuroblastoma. Nishimura R, Tabata K, Arakawa M, Ito Y, Kimura Y, Akihisa T, Nagai H, Sakuma A, Kohno H, Suzuki T. Biol Pharm Bull. 2007 Oct;30(10):1878-83.
Xanthoangelol, a major chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma and leukemia cells. Tabata K, Motani K, Takayanagi N, Nishimura R, Asami S, Kimura Y, Ukiya M, Hasegawa D, Akihisa T, Suzuki T. Biol Pharm Bull. 2005 Aug;28(8):1404-7. PMID: 16079483 [PubMed - indexed for MEDLINE]
Antitumor and antimetastatic activities of 4-hydroxyderricin isolated from Angelica keiskei roots.Kimura Y, Taniguchi M, Baba K. Planta Med. 2004 Mar;70(3):211-9. PMID: 15114497 [PubMed - indexed for MEDLINE]
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects. Akihisa T, Tokuda H, Hasegawa D, Ukiya M, Kimura Y, Enjo F, Suzuki T, Nishino H. J Nat Prod. 2006 Jan;69(1):38-42 - - inhibitory effects on the induction of Epstein-Barr virus, - - inhibitory effects on skin tumor promotion
Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects. Akihisa T, Tokuda H, Ukiya M, Iizuka M, Schneider S, Ogasawara K, Mukainaka T, Iwatsuki K, Suzuki T, Nishino H. Cancer Lett. 2003 Nov 25;201(2):133-7 - - antitumor-promoters
In vitro induction of the anticarcinogenic marker enzyme, quinone reductase, in human hepatoma cells by food extracts.
Hashimoto K, Kawamata S, Usui N, Tanaka A, Uda Y. Cancer Lett. 2002 Jun 6;180(1):1-5.
Anti-tumor-promotion by principles obtained from Angelica keiskei. Okuyama T, Takata M, Takayasu J, Hasegawa T, Tokuda H, Nishino A, Nishino H, Iwashima A. Planta Med. 1991 Jun;57(3):242-6.
Potent antimitotic and cell growth inhibitory properties of substituted chalcones, S. Ducki, R. Forrest, et al.,. Med. Chem. Lett., 1998, 8, 1051.
Ashitaba Helps to Inhibit Cancer: Linked Parallel Synthesis and MTT Bioassay Screening of Substituted Chalcones, N. J. Lawrence, D. Rennison, A. T. et al., Chem., 2001, 3, in press.
The Interaction of Chalcones with Tubulin, N. J. Lawrence, A. T. McGown, S. Ducki and J. A. Hadfield, Anticancer Drug Design, 2000, 15, 135.
Effect of naturally occurring coumarins on the formation of epidermal DNA adducts and skin tumors induced by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in SENCAR mice. Cai Y, Kleiner H, Johnston D, Dubowski A, Bostic S, Ivie W, DiGiovanni J.
Isobavachalcone, a Chalcone Constituent of Angelica keiskei, Induces Apoptosis in Neuroblastoma. Nishimura R, Tabata K, Arakawa M, Ito Y, Kimura Y, Akihisa T, Nagai H, Sakuma A, Kohno H, Suzuki T. Biol Pharm Bull. 2007 Oct;30(10):1878-83.
Xanthoangelol, a major chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma and leukemia cells. Tabata K, Motani K, Takayanagi N, Nishimura R, Asami S, Kimura Y, Ukiya M, Hasegawa D, Akihisa T, Suzuki T. Biol Pharm Bull. 2005 Aug;28(8):1404-7. PMID: 16079483 [PubMed - indexed for MEDLINE]
Antitumor and antimetastatic activities of 4-hydroxyderricin isolated from Angelica keiskei roots.Kimura Y, Taniguchi M, Baba K. Planta Med. 2004 Mar;70(3):211-9. PMID: 15114497 [PubMed - indexed for MEDLINE]
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects. Akihisa T, Tokuda H, Hasegawa D, Ukiya M, Kimura Y, Enjo F, Suzuki T, Nishino H. J Nat Prod. 2006 Jan;69(1):38-42 - - inhibitory effects on the induction of Epstein-Barr virus, - - inhibitory effects on skin tumor promotion
Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects. Akihisa T, Tokuda H, Ukiya M, Iizuka M, Schneider S, Ogasawara K, Mukainaka T, Iwatsuki K, Suzuki T, Nishino H. Cancer Lett. 2003 Nov 25;201(2):133-7 - - antitumor-promoters
 |
| Cancer |
In April of 2007, Corky, our 6-year young Labrador Retriever had surgery to remove and biopsy a strange small growth along the gum line of her lower jaw. Later … identified as a plasmacytoma. The vet told us that he could not remove the whole tumor due to its location Corky also started showing signs of depression, lack of energy, and pain.
…the tumor was coming back. It had actually quadrupled in size and was ulcerated at this point. We … were told that we had two options: 1) remove a large section of her lower jaw bone, or 2) start focalized radiation therapy (20 visits approx.). … Here we are today, 3 months later, and Corky has no signs of this cancerous growth! Amazingly it has disappeared! In addition, her energy has returned, she has a sparkle in her eyes and a beautiful coat.
I would like to have you use this information in order to help other people and animals that are impacted by cancer.
By the way, my boyfriend and I have also noticed the benefits of Ashitaba Green! We couldn’t be happier! I tell everyone I know about your product and everyone that I pass it on to calls to thank me.We are forever indebted to you for providing Ashitaba Green which saved Corky’s life!
Warmest regards, Dawn 09/12/2007
Ashitaba Green and Cancer
We use oxygen from the air to oxidize our food to provide the energy we need for our cells to function. Sometimes, however, those oxidation reactions release uncontrolled reactants called free radicals. Free radicals can and will react with many different important molecules, including lipids, proteins and DNA, damaging them in the process. When, a cell's DNA gets damaged, it can lead to mutations which in turn can bring about cancer.
Normally functioning cells process oxidative free radicals appropriately, Sometimes the body's immune system's cells purposefully create them to neutralize viruses and bacteria. However, environmental factors such as pollution, radiation, cigarette smoke and herbicides can also cause the body to spawn free radicals and if antioxidants are unavailable, or if the free-radical production becomes excessive, then even a healthy system can become overwhelmed. Of particular importance is that free radical damage accumulates with age.
Toxins tend to concentrate in the liver and gastrointestinal tract.
When the gastrointestinal tract (digestive system) becomes sluggish, over-acid, and toxic it becomes less and less efficient and therefore unable to supply the necessary nutrients to feed the heart, lungs, brain, muscles, etc. This can reduce metabolic activity, drain the body of energy and make one more susceptible to disease and infection and less able to rid oneself of toxins - creating an ever declining state of health.
The FDA has shown that a diet high in fiber can reduce the risk of colon cancer by 40% and this is why it now recommends the minimum of five servings of fruit and vegetables a day. Okinawans eat at least seven servings of vegetables daily (including ashitaba) and boast the highest percentage of centenarians anywhere. "heart disease rates are low: 80% fewer heart attacks than Americans, and Okinawans who have heart attacks are more likely to survive. Breast and prostate cancer are so rare as to be unheard of among the older population. Obesity is equally rare." (Okinawan food guide)
Ashitaba Green being a whole food product is high in fiber and being a green food, it can help lower acidity. Insoluble fiber is necessary for elimination in the digestive system.
When the liver becomes sluggish and weak, toxins accumulate in the blood and reduce the capability of the blood to absorb and transport oxygen to the tissues of the body. Without oxygen, we are devitalized, and according to some theories, the tissues go into a morbid state in which they can survive on fermentation rather than oxygenation. This is what is referred to as anaerobic and it is believed, by such persons as Nobel laureate Prof. Otto Warburg, that cancer thrives in such oxygen deficient conditions.
Ashitaba has long been used in Traditional Chinese Medicine to strengthen the liver and kidneys.
To prevent diseases like cancer it is necessary for us to cleanse, nourish and heal our bodies (see Dr Christopher's message) on a daily basis so as to restore our cells and protect them from damage.
Ashitaba has been shown to have anticarcinogenic, antitumor, antimetastatic and antimitotic properties.
We use oxygen from the air to oxidize our food to provide the energy we need for our cells to function. Sometimes, however, those oxidation reactions release uncontrolled reactants called free radicals. Free radicals can and will react with many different important molecules, including lipids, proteins and DNA, damaging them in the process. When, a cell's DNA gets damaged, it can lead to mutations which in turn can bring about cancer.
Normally functioning cells process oxidative free radicals appropriately, Sometimes the body's immune system's cells purposefully create them to neutralize viruses and bacteria. However, environmental factors such as pollution, radiation, cigarette smoke and herbicides can also cause the body to spawn free radicals and if antioxidants are unavailable, or if the free-radical production becomes excessive, then even a healthy system can become overwhelmed. Of particular importance is that free radical damage accumulates with age.
Toxins tend to concentrate in the liver and gastrointestinal tract.
When the gastrointestinal tract (digestive system) becomes sluggish, over-acid, and toxic it becomes less and less efficient and therefore unable to supply the necessary nutrients to feed the heart, lungs, brain, muscles, etc. This can reduce metabolic activity, drain the body of energy and make one more susceptible to disease and infection and less able to rid oneself of toxins - creating an ever declining state of health.
The FDA has shown that a diet high in fiber can reduce the risk of colon cancer by 40% and this is why it now recommends the minimum of five servings of fruit and vegetables a day. Okinawans eat at least seven servings of vegetables daily (including ashitaba) and boast the highest percentage of centenarians anywhere. "heart disease rates are low: 80% fewer heart attacks than Americans, and Okinawans who have heart attacks are more likely to survive. Breast and prostate cancer are so rare as to be unheard of among the older population. Obesity is equally rare." (Okinawan food guide)
Ashitaba Green being a whole food product is high in fiber and being a green food, it can help lower acidity. Insoluble fiber is necessary for elimination in the digestive system.
When the liver becomes sluggish and weak, toxins accumulate in the blood and reduce the capability of the blood to absorb and transport oxygen to the tissues of the body. Without oxygen, we are devitalized, and according to some theories, the tissues go into a morbid state in which they can survive on fermentation rather than oxygenation. This is what is referred to as anaerobic and it is believed, by such persons as Nobel laureate Prof. Otto Warburg, that cancer thrives in such oxygen deficient conditions.
Ashitaba has long been used in Traditional Chinese Medicine to strengthen the liver and kidneys.
To prevent diseases like cancer it is necessary for us to cleanse, nourish and heal our bodies (see Dr Christopher's message) on a daily basis so as to restore our cells and protect them from damage.
Ashitaba has been shown to have anticarcinogenic, antitumor, antimetastatic and antimitotic properties.
Contact Information
Solusi Energi Plus Co.
Office:
Gayungsari Barat III No. 68. Surabaya, Indonesia
Home:
Simpang Darmo Permai Selatan XI No. 61, Surabaya, Indonesia
Mobile Phone:
+62 81230797372 - +62 8 1515 1818 23 - +62 87853532923
Email:
ekaprabhana1@yahoo.co.id & ekaprabhana2@yahoo.co.id
Website:
• www.ashitaba-chalcone.blogspot.com (Ashitaba is Angel of Herb with Chalcone and The Only One in The World)
• www.blood-birdnest.blogspot.com (Blood Bird Nest is Scarce Nest and The Only One in The World)
• www.wild-civetcoffee.blogspot.com (Wild Civet Coffee is Unique Coffee and The Only One in The World)
• www.pasakbumi-extract200 (Pasak Bumi is Rare Root and The Only One in The World for Biggest Plantation than The Other)
Note:
1. See in www.youtube.com with title Ashitaba is Angel of Herb with Chalcone and The Only One in The World 2: http://www.youtube.com/watch?v=rJotaT7Bw8o
2. See in www.youtube.com with title Red-Blood Bird Nest 1: http://www.youtube.com/watch?v=xxFFDAS_9ZI
Office:
Gayungsari Barat III No. 68. Surabaya, Indonesia
Home:
Simpang Darmo Permai Selatan XI No. 61, Surabaya, Indonesia
Mobile Phone:
+62 81230797372 - +62 8 1515 1818 23 - +62 87853532923
Email:
ekaprabhana1@yahoo.co.id & ekaprabhana2@yahoo.co.id
Website:
• www.ashitaba-chalcone.blogspot.com (Ashitaba is Angel of Herb with Chalcone and The Only One in The World)
• www.blood-birdnest.blogspot.com (Blood Bird Nest is Scarce Nest and The Only One in The World)
• www.wild-civetcoffee.blogspot.com (Wild Civet Coffee is Unique Coffee and The Only One in The World)
• www.pasakbumi-extract200 (Pasak Bumi is Rare Root and The Only One in The World for Biggest Plantation than The Other)
Note:
1. See in www.youtube.com with title Ashitaba is Angel of Herb with Chalcone and The Only One in The World 2: http://www.youtube.com/watch?v=rJotaT7Bw8o
2. See in www.youtube.com with title Red-Blood Bird Nest 1: http://www.youtube.com/watch?v=xxFFDAS_9ZI
Langganan:
Postingan (Atom)
